Global antimicrobial resistance is on the rise. Antimicrobial resistance affects warfighters and military personnel both on the battlefield and off. Combat wounds can be contaminated with environmental bacteria, such as S. aureus, that may confer resistance to conventional antibiotics. This was demonstrated in 2008, when multi-drug resistant bacteria were cultured from the wounds of soldiers who suffered injuries in Iraq and Afghanistan. Antibacterial resistance has challenged military medicine since the discovery of penicillin. However, the situation today is compounded by the fact that no new antibiotic classes have been discovered since 1984. The U.S. Centers for Disease Control and Prevention calls this “one of the biggest health challenges of our time,” and the World Health Organization cautions that a possible “post-antibiotic era” is on the horizon.