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Vesicular Stomatitis Virus-Based Vaccines Against Lassa and Ebola Viruses.

Summary

We demonstrated that previous vaccination with a vesicular stomatitis virus (VSV)–based Lassa virus vaccine does not alter protective efficacy of subsequent vaccination with a VSV-based Ebola virus vaccine. These findings demonstrate the utility of VSV-based vaccines against divergent viral pathogens, even when preexisting immunity to the vaccine vector is present.

Subject Keywords

VACCINES, EBOLA, SEQUENTIAL VACCINATION, LASSA VIRUS, NONHUMAN PRIMATES, VIRAL HEMORRHAGIC FEVER, EXISTING IMMUNITY, BIOLOGICAL DECONTAMINATION, VESICULAR STOMATITIS VIRUS (VSV), WEST AFRICA

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