PTSD: Applications & Future Directions in Behavioral Medicine & Clinical Neuroscience

Global conflict and political instability have increased our nation’s military operations and deployments. Missions occur more frequently, in unpredictable environments, resulting in less time for soldiers to recover mentally and physically. Many active duty service members return from combat with symptoms related to post-traumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI). Although research in these areas is on-going, accurate reporting and assessment and effective interventions are lacking. Understanding the progression of PTSD, the neural mechanisms involved, and the compounding impact of mTBI and other comorbidities is imperative. Increased knowledge will enable the military to improve in first-line interventions, including predictive and resilience training.

This State of the Art Report (SOAR) presents recent research in behavioral medicine and clinical neuroscience as it relates to PTSD, which often occurs with mTBI and other comorbidities. Current gaps in knowledge and treatment ineffectiveness underscore the need for the military to more specifically and comprehensively address military-related PTSD and mTBI in active duty soldiers and veterans. Of particular interest are new scientific perspectives driving research and shifting paradigms; innovative technologies for delivering interventions; and emerging research in predictive and resilience training.

Uses of Nanotechnology on Surfaces for Military Applications

Nanotechnology is the manipulation of matter at an atomic level to produce new materials, referred to as engineered nanomaterials. Particles at this scale typically range in sizes from 1 to 100 nanometers (nm) in at least one dimension. A nm is one-billionth of a meter. To put this into perspective, DNA is 2 nm wide, and a human hair is approximately 50,000 nm wide. At this scale, the physicochemical properties of particles behave very differently than larger particles of similar composition. The characteristics of these particles make them highly desirable for certain applications. One of the most exciting developments of engineered nanomaterials is in surfaces used for military purposes. The Department of Defense (DoD) is scheduled to spend more than $130 million on nanotechnology research in Fiscal Year (FY) 2017. The National Nanotechnology Initiative (NNI), a major federal nanotechnology research initiative, directly supports eight DoD research and development (R&D) organizations. The DoD has been a member of the NNI since its inception in 2000; however, the state of nanotechnology and its incorporation into defense strategy has changed over the past 16 years. Although the majority of nanotechnology research is still many years away from being commercialized for practical use, some current applications of engineered nanomaterials and some late-stage research show promise for enhancing the performance of military products. Because surfaces almost exclusively dictate the functionality of an object and often can be modified with great success, nanotechnology and nanomaterials are increasingly important to the military. This state of the art report (SOAR) provides the DoD with an overview of some of the most promising new- and close-to-market nanotechnologies with military applications, along with a compendium of practical knowledge that can be used to develop a research strategy and streamline acquisition of new nanotechnologies and materials.